14 Apr 2025, 12:30

Dear Students and Colleagues,

You are cordially invited to the lecture of MU Life Sciences Seminar:

"Structure-guided Development of Therapeutic and Diagnostic Solutions for Chagas’ Disease" by Dr Ivan Campeotto, (University of Nottingham, UK).

WHEN: Thursday, April 17, 2025, at 4 p.m.
WHERE: Seminar room 132, pavilion B11, University Campus Bohunice

Remember to bring your ISIC card to the lecture.

Hřbet ruky s ukazovákem ukazujícím vpravoPhD students who would like to attend a sponsored lunch with our speaker (Thursday, at 13:00 at Campus River), please register by Wednesday 16, 2025 using the form at the website.

With best regards,
Linda Nosková
MU LSS administrator
noskova@sci.muni.cz

Life Sciences Seminar - Programme for Spring 2025

About the Lecture

Structure-guided Development of Therapeutic and Diagnostic Solutions for Chagas’ Disease

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is an increasing global public health concern killing 12,000 people per annum worldwide and infecting eight million individuals, with the majority remaining undiagnosed. Despite its profound health impact in both endemic and non-endemic areas, no vaccine is available, and the existing therapies are outdated, producing severe side effects.

Two conserved T. cruzi antigens, called Tc80 and Tc24, have recently been identified as the key factors for invasion and are the leading candidates for a Chagas vaccine.
In this seminar, we will present the cryo-EM structures of Tc80 in open and closed conformation and discuss on-going work to characterise the immunogenicity of both antigens, using an integrative structural approach towards new therapeutic and diagnostic solutions for Chagas disease.

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Masaryk University