Lecture will be held in English

Hosted by

Barbora Pafčo

About the lecture

Structure-guided Development of Therapeutic and Diagnostic Solutions for Chagas’ Disease

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is an increasing global public health concern killing 12,000 people per annum worldwide and infecting eight million individuals, with the majority remaining undiagnosed. Despite its profound health impact in both endemic and non-endemic areas, no vaccine is available, and the existing therapies are outdated, producing severe side effects.
In this seminar, we will present the cryo-EM structures of Tc80 in open and closed conformation and discuss on-going work to characterise the immunogenicity of both antigens, using an integrative structural approach towards new therapeutic and diagnostic solutions for Chagas disease.

Registration for lunch with the speaker /for Ph.D. students/

The sponsored lunch usually takes place in the Campus River restaurant. Please meet the speaker and other students at 12:45 at the reception desk at the main entrance (building B22, see the map below).