Lecture will be held in English

Hosted by

Petr Beneš

About the lecture

Tumor Endothelium as a Modulator of Immune Responses in Cancer Metastasis

Endothelial cells not only make up the lining of blood vessels but also contribute to tissue-specific and vessel type specific niche formations required during inflammation and cancer. Importantly, endothelium activation promotes leukocyte recruitment. Accumulating evidence indicates an active involvement of endothelium in immunomodulation during tumorigenesis. We will discuss current data on a co-stimulatory immune receptor expression in tumor vasculature and its role during tumorigenesis and metastasis. Using endothelial-specific deletion, we observed not only differences in tumor angiogenesis, but also changes in the tumor microenvironment, including immune cells. Analysis of several metastatic models revealed tissue-specific modulation of tumor immune responses.

Registration for lunch with the speaker /for Ph.D. students/

The sponsored lunch usually takes place in the Campus River restaurant. Please meet the speaker and other students at 12:45 at the reception desk at the main entrance (building B22, see the map below).