Anthony Davis: Biosupramolecular Chemistry: towards Anion and Carbohydrate Receptors with Biomedical Applications 

10. 5. 2018, University Campus Bohunice

About the lecture

Supramolecular chemistry has a productive relationship with biology. The supramolecular chemist can learn from biomolecules while helping to explain their properties, and the biomedical area provides opportunities for important applications. This lecture will describe work from two programmes aimed at systems which can not only mimic the functions of biomolecules but are sufficiently effective to be useful in research and medicine. The first programme involves a series of molecules which can carry anions across cell membranes. 

These anionophores could potentially replace the activity of natural anion channels which are missing or defective, and thus to treat the resulting conditions (notably cystic fibrosis). The second programme involves the design of receptors which bind carbohydrates in water, one of the more difficult challenges in supramolecular chemistry. The resulting molecules have potential in carbohydrate sensing, in exploiting polysaccharides, and as “synthetic antibodies” which can complement natural carbohydrate-binding proteins.

Prof. Anthony Davis

University of Bristol, UK

  • Tony Davis gained a B.A. in Chemistry from Oxford University in 1977, then stayed on for a D.Phil. under Dr. G. H. Whitham and two years’ postdoctoral work with Prof. J. E. Baldwin.
  • In 1981 he moved to the ETH Zürich as a Royal Society European Exchange Fellow working with Prof. A. Eschenmoser, then in 1982 was appointed as a Lecturer in Organic Chemistry at Trinity College, Dublin.
  • In September 2000 he moved to the University of Bristol, where he is Professor of Supramolecular Chemistry in the School of Chemistry.
  • In 2002 he received the Tilden Medal from the Royal Society of Chemistry, and in 2015 the RSC Award for Physical Organic Chemistry.
  • He is currently a member of the Editorial Board of Organic and Biological Chemistry.
  • Laboratory web: https://davis.chm.bris.ac.uk/