About the lecture
We use NMR spectroscopy to directly study proteins in live cells. Having established the experimental reference frame for investigating the human amyloid protein alpha-synuclein in healthy neuronal and non-neuronal cells, I present new data on the fate and basic biological function(s) of this protein in different mammalian cell types.
Our results reveal surprising new insights into the role of alpha-synuclein in binding to unique physiological membranes.
Dr. Phil Selenko
Leibniz Institute of Molecular Pharmacology, Berlin
- He works at the interface of cell biology and biophysics to study the structural and functional in vivo properties of proteins inside cells.
- His primary research tool is liquid-state NMR spectroscopy, which he employs for high-resolution in-cell NMR measurements.
- The main focus of the group is to learn about the structural characteristics of intrinsically unfolded proteins (IDPs) in their native cellular environments and about post-translational protein modifications and their influence on protein structure and function.
- He complements in-cell NMR methods with techniques in cell biology, biochemistry and biophysics.
- Laboratory webpage: http://www.incellnmr.net/