About the lecture
B and T lymphocytes develop in the bone marrow and thymus respectively, in both cases progressing through a series of precursor populations where the immunoglobulin or T cell antigen receptor (TCR) genes undergo ordered rearrangements. Signals from surface-bound immunoglobulin, the B cell antigen receptor (BCR) or the TCR control the development of B and T cells allowing progression only to cells that express functional non-autoreactive antigen receptors. Once mature lymphocytes have been generated, signalling pathways control the activation, survival, and function of the cells. I will discuss the use of mouse genetic and biochemical approaches to understand how signals control these diverse cellular processes in the animal. Most recently we have uncovered a completely novel pathway that controls the adhesion and migration of B and T cells and contributes significantly to the adaptive immune response.
Dr. Victor Tybulewicz
Francis Crick Institute, London, UK
My group is interested in signal transduction in B and T cells, from the antigen, chemokine and cytokine receptors, as well as integrins. Signals from these receptors play critical roles in B and T cell development, activation, migration, survival and death.
We are studying how signalling pathways control these processes, using mouse genetics, protein biochemistry, imaging, cell biology, and RNAi and CRISPR screens. Current research interests include pathways controlling B and T cell migration and adhesion, B cell survival, the biology of memory B cells and the function of long non-coding RNAs in lymphocyte biology.