Victor Tybulewicz: Signal Transduction Pathways Controlling B and T Cell Development, Survival and Function

26. 10. 2017, University Campus Bohunice

About the lecture

B and T lymphocytes develop in the bone marrow and thymus respectively, in both cases progressing through a series of precursor populations where the immunoglobulin or T cell antigen receptor (TCR) genes undergo ordered rearrangements. Signals from surface-bound immunoglobulin, the B cell antigen receptor (BCR) or the TCR control the development of B and T cells allowing progression only to cells that express functional non-autoreactive antigen receptors. Once mature lymphocytes have been generated, signalling pathways control the activation, survival, and function of the cells. I will discuss the use of mouse genetic and biochemical approaches to understand how signals control these diverse cellular processes in the animal. Most recently we have uncovered a completely novel pathway that controls the adhesion and migration of B and T cells and contributes significantly to the adaptive immune response.

Dr. Victor Tybulewicz

Francis Crick Institute, London, UK

  • My group is interested in signal transduction in B and T cells, from the antigen, chemokine and cytokine receptors, as well as integrins. Signals from these receptors play critical roles in B and T cell development, activation, migration, survival and death.

  • We are studying how signalling pathways control these processes, using mouse genetics, protein biochemistry, imaging, cell biology, and RNAi and CRISPR screens. Current research interests include pathways controlling B and T cell migration and adhesion, B cell survival, the biology of memory B cells and the function of long non-coding RNAs in lymphocyte biology.

  • Laboratory webpage: https://www.crick.ac.uk/research/a-z-researchers/researchers-t-u/victor-tybulewicz/projects/