Prof. Alexander Stark
Research Institute of Molecular Pathology, Austria
Our aim is to understand how transcription is regulated at the level of the two key types of regulatory genomic elements – enhancers and core-promoters – and the transcription factor and cofactor proteins that mediate transcription activation.
To reach this goal, we follow an interdisciplinary approach, using genome-wide functional assays, bioinformatics, biochemistry, and mass-spectrometry. We develop and employ highly-controllable reporter assays that provide reliable functional readouts for each of the questions we ask, while circumventing the many confounding issues that exist in complex gene regulatory systems in vivo.
See more information at the webpage of Prof. Stark´s group.