Understanding the multiple functions of human telomeres

  • 19 May 2022
    4:00 PM
  • University Campus Bohunice (pavilion B11/ seminar room 132)

Lecture will be held in English


Assoc. Prof. Jayakrishnan (JK) Nandakumar, Ph.D.
"We study telomeres and telomerase, which are protein-nucleic acid complexes that act on all eukaryotic chromosome ends. Telomeres ensure that our chromosome ends do not engage in illicit inter-chromosomal fusion events that could lead to various diseases including cancer."

Link to Nandakumar Labs websites

Hosted by

Ctirad Hofr

About the lecture

Understanding the multiple functions of human telomeres

Abstract: Telomeres are essential structures at chromosome functions that perform three functions. They protect chromosome ends from the DNA damage response and repair machinery to prevent illicit chromosome fusion, recombination, and deletion. They help replicate the ends of chromosomes in actively dividing cells like stem cells by recruiting the end-replicating enzyme telomerase. Finally, telomeres tether to the nuclear envelope during prophase I of meiosis to connect to the cytosolic dynein machinery and facilitate chromosome movements that are central to homolog pairing and meiotic crossover. Our lab uses a combination of biochemistry, structural biology, and cell biology to provide molecular insights into the functions of mammalian telomeres. My talk will detail the recent progress that our research group has made to understand how human telomerase is recruited to telomeres, how human telomeres attach to the nuclear envelope during meiosis, and how dynein connects to meiotic telomeres and moves them to facilitate meiotic crossover.

Registration for lunch with the speaker /for Ph.D. students/

The sponsored lunch usually takes place in the Campus River restaurant. Please meet the speaker and other students at 12:45 at the reception desk at the main entrance (building B22, see the map below).


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