Dynamic Recoding of the Transcriptome:How RNA Modifications Control Hypertension
24 October 2019
- University Campus Bohunice (pavilion B11/ seminar room 132)
Prof. Michael Jantsch
Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Austria
"We use transgenic mice, cell biological tools, and transcriptome analyses to study the consequences of RNA-editing events. Using mice deficient in either of the two RNA-editing enzymes ADAR1 or ADAR2 we study the interplay of these two enzymes with other RNA processing machineries. A mouse model specifically defective in filamin A pre-mRNA editing is used to study the consequences of this highly conserved RNA-editing event."
See more information about Prof. Jantsch´s research here.
About the lecture
Adenosine deamination is one of the most abundant types of RNA modification found in mammals. When adenosines become deaminated to inosines they can be interpreted as guanosines, adenosines, or even uracil. While most adenosine deamination affects repeat-derived RNAs, several highly conserved modifications can be found across most vertebrates that lead to protein recoding.
An abundant editing-induced recoding event is found in the pre-mRNAs encoding the actin-crosslinking proteins filamin A and filamin B. Mice deficient in filamin A editing show altered smooth muscle contraction ultimately affecting blood pressure control. The seminar will discuss biological consequences of this editing event as well as its dynamic regulation.