Prof. Michal Hocek, Ph.D., DSc.

Head of the Senior Research Group, Institute of Organic Chemistry and Biochemistry ASCR, v.v.i. & Dept. of Organic Chemistry, Faculty of Science, Charles University, Prague, Czech Republic

Main research interests: 

• chemistry of nucleobases, nucleosides, nucleotides and nucleic acids
• application of transition metal-catalyzed reactions in organic synthesis
• medicinal chemistry
• chemical biology

See more information at Prof. Hocek´s research group website.

Hosted by

Vladimír Sklenář

About the lecture

The talk will summarize our most recent findings in development of new methods of synthesis of modified nucleoside triphosphates and enzymatic synthesis of base-modified nucleic acids (DNA or RNA) through polymerase incorporation of the modified nucleotides.¹  The modified nucleic acids are applied in diagnostics (environment-sensitive fluorescent labelling, redox labelling etc.)² and chemical biology (bioconjugations, cross-linking with proteins, regulation of protein-DNA binding and switching transcription).³

1. (a) Hocek, M. Acc. Chem. Res. 2019, 52, 1730-1737. (b) Kielkowski, P.; Fanfrlík, J.; Hocek, M. Angew. Chem. Int. Ed. 2014, 53, 7552-7555.
2. (a) Balintová, J.; Špaček, J.; Pohl, R.; Brázdová, M.; Havran, L.; Fojta, M.; Hocek, M. Chem. Sci. 2015, 6, 575-587. (b) Dziuba, D.; Jurkiewicz, P.; Cebecauer, M.; Hof, M.; Hocek, M. Angew. Chem. Int. Ed. 2016, 55, 174-178. (c) Matyašovský, J.; Perlíková, P.; Malnuit, V.; Pohl, R.; Hocek, M. Angew. Chem. Int. Ed. 2016, 55, 15856-15859.
3. (a) Dadová, J.; Orság, P.; Pohl, R.; Brázdová, M.; Fojta, M.; Hocek, M. Angew. Chem. Int. Ed. 2013, 52, 10515-10518. (b) Vaníková, Z.; Janoušková, M.; Kambová, M.; Krásný, L.; Hocek, M. Chem. Sci. 2019, 10, 3937-3942. (d) Ivancová, I.; Pohl, R.; Hubálek, M.; Hocek, M. Angew. Chem. Int. Ed. 2019, 58, 13345-13348.

Registration for lunch with the speaker /for Ph.D. students/

The sponsored lunch usually takes place in the Campus River restaurant. Please meet the speaker and other students at 12:45 in the Atrium of CEITEC building E35.