Base-Modified Nucleic Acids for Applications in Diagnostics or Chemical Biology

  • 21 October 2021
    4:00 PM
  • University Campus Bohunice (pavilion B11/ seminar room 132)

Speaker

Prof. Michal Hocek, Ph.D., DSc.

Head of the Senior Research Group, Institute of Organic Chemistry and Biochemistry ASCR, v.v.i. & Dept. of Organic Chemistry, Faculty of Science, Charles University, Prague, Czech Republic

Main research interests: 

  • chemistry of nucleobases, nucleosides, nucleotides and nucleic acids
  • application of transition metal-catalyzed reactions in organic synthesis
  • medicinal chemistry
  • chemical biology

See more information at Prof. Hocek´s research group website.

About the lecture

The talk will summarize our most recent findings in development of new methods of synthesis of modified nucleoside triphosphates and enzymatic synthesis of base-modified nucleic acids (DNA or RNA) through polymerase incorporation of the modified nucleotides.1  The modified nucleic acids are applied in diagnostics (environment-sensitive fluorescent labelling, redox labelling etc.)2 and chemical biology (bioconjugations, cross-linking with proteins, regulation of protein-DNA binding and switching transcription).3

  1. (a) Hocek, M. Acc. Chem. Res. 2019, 52, 1730-1737. (b) Kielkowski, P.; Fanfrlík, J.; Hocek, M. Angew. Chem. Int. Ed. 2014, 53, 7552-7555.
  2. (a) Balintová, J.; Špaček, J.; Pohl, R.; Brázdová, M.; Havran, L.; Fojta, M.; Hocek, M. Chem. Sci. 2015, 6, 575-587. (b) Dziuba, D.; Jurkiewicz, P.; Cebecauer, M.; Hof, M.; Hocek, M. Angew. Chem. Int. Ed. 2016, 55, 174-178. (c) Matyašovský, J.; Perlíková, P.; Malnuit, V.; Pohl, R.; Hocek, M. Angew. Chem. Int. Ed. 2016, 55, 15856-15859.
  3. (a) Dadová, J.; Orság, P.; Pohl, R.; Brázdová, M.; Fojta, M.; Hocek, M. Angew. Chem. Int. Ed. 2013, 52, 10515-10518. (b) Vaníková, Z.; Janoušková, M.; Kambová, M.; Krásný, L.; Hocek, M. Chem. Sci. 2019, 10, 3937-3942. (d) Ivancová, I.; Pohl, R.; Hubálek, M.; Hocek, M. Angew. Chem. Int. Ed. 2019, 58, 13345-13348.

 

Registration for lunch with the speaker /for Ph.D. students/

The sponsored lunch usually takes place in the Campus River restaurant. Please meet the speaker and other students at 12:45 in the Atrium of CEITEC building E35.






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