Personalizing the treatment of Parkinson’s disease using a multi-sensor integrated midbrain organoid-on-a-chip platform
12 May 2022
- University Campus Bohunice (pavilion B11/ seminar room 132)
Lecture will be held in English
About the lecture
In recent years midbrain organoid technology has significantly advanced Parkinson’s disease modelling due to its ability to recapitulate the key pathological processes including dopaminergic neurodegeneration and alpha-synuclein accumulation. However, some limitations such as tissue immaturity, insufficient nutrient supply as well as low analytical accessibility persist, thus limiting the technology’s full potential. To overcome these drawbacks, we have integrated patient derived midbrain organoids into a multi-sensor organ-on-a-chip platform capable of monitoring electrophysiological activity, neurotransmitter release and metabolic activity during onset and progression of Parkinson’s disease. In the presentation Organ-on-a-chip design and fabrication issues including integrated optical and electrical sensing methods as well as on-chip disease modelling as novel tool for personalized medicine will be discussed.
Registration for lunch with the speaker /for Ph.D. students/
The sponsored lunch usually takes place in the Campus River restaurant. Please meet the speaker and other students at 12:45 at the reception desk at the main entrance (building B22, see the map below).