Personalizing the treatment of Parkinson’s disease using a multi-sensor integrated midbrain organoid-on-a-chip platform

  • 12 May 2022
    4:00 PM
  • University Campus Bohunice (pavilion B11/ seminar room 132)

Lecture will be held in English


Prof. Dr. Peter Ertl
"The aim of personalized medicine (or precision medicine) is to take patients’ personal features into consideration as much as possible for their medical treatment, thereby going beyond the functional diagnosis of the disease. To do so, patients’ predispositions to a disease are determined, taking into account phenotypes and genotypes, diagnostic imaging and information about their lifestyles, to tailor preventive measures and targeted, optimized therapies. A promising concept that is gaining ever more attention and showing potential for both personalized medicine and pharmaceutical research is “organ-on-a-chip” technology."

Link to Prof. Dr. Peter Ertl´s websites or more about his research.

Hosted by

Zbyněk Prokop

About the lecture

In recent years midbrain organoid technology has significantly advanced Parkinson’s disease modelling due to its ability to recapitulate the key pathological processes including dopaminergic neurodegeneration and alpha-synuclein accumulation. However, some limitations such as tissue immaturity, insufficient nutrient supply as well as low analytical accessibility persist, thus limiting the technology’s full potential. To overcome these drawbacks, we have integrated patient derived midbrain organoids into a multi-sensor organ-on-a-chip platform capable of monitoring electrophysiological activity, neurotransmitter release and metabolic activity during onset and progression of Parkinson’s disease. In the presentation Organ-on-a-chip design and fabrication issues including integrated optical and electrical sensing methods as well as on-chip disease modelling as novel tool for personalized medicine will be discussed.

Registration for lunch with the speaker /for Ph.D. students/

The sponsored lunch usually takes place in the Campus River restaurant. Please meet the speaker and other students at 12:45 at the reception desk at the main entrance (building B22, see the map below).


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