From Hedgehog Signalling to Myogenesis
5 May 2022
- University Campus Bohunice (pavilion B11/ seminar room 132)
Lecture will be held in English
Prof. Philip William Ingham
"My research has always aimed to understand complex biological processes by studying them in the context of the whole organism. My group uses a genetically tractable organism, the tropical fish Danio rerio (commonly known as the zebrafish), as a model in which to unravel the molecular and cellual basis of human development and disease. Zebrafish not only offer exceptional opportunities for in vivo imaging, genetic manipulation and high throughput drug screening, but also address the aims of the 3Rs – Reduction, Refinement, Replacement - in animal research."
Link to websites
About the lecture
Hedgehog (Hh) proteins constitute one family of a small number of secreted signals that together regulate multiple aspects of animal development, tissue homeostasis and regeneration. Originally uncovered through genetic analyses in Drosophila, their subsequent discovery in vertebrates has provided a paradigm for the role of morphogens in positional specification. Most strikingly, the Sonic hedgehog protein was shown to mediate the activity of two classic embryonic organizing centres in vertebrates and subsequent studies have implicated it and its paralogues in a myriad of processes. In this talk I will first review the genetic studies that uncovered the key components of the Hh signalling system and the subsequent, biochemical, cell and structural biology analyses of their functions. I will next describe our studies in zebrafish that revealed a central role for Hh signalling in the generation of skeletal muscle fibre identity. Finally, I will present our unpublished studies of Hh-independent post embryonic myogenesis and muscle fibre type plasticity.
Registration for lunch with the speaker /for Ph.D. students/
The sponsored lunch usually takes place in the Campus River restaurant. Please meet the speaker and other students at 12:45 at the reception desk at the main entrance (building B22, 2nd floor - see the map below).