Institute of Molecular Genetics of the ASCR, v. v. i., Czech Republic
Director of Dept. of Transgenic Models of Diseases & Transgenic Unit, IMG ASCR, v. v. i.
Main research topics: Mouse models of diseases, ubiquitin ligases, proteases and their inhibitors, epidermis, genome editing.
See more information about Radislav Sedlacek here.
The Czech Centre for Phenogenomics (CCP, Institute of Molecular Genetics) is the largest non-distributed biomedical research infrastructure in the Czech Republic with international significance, providing a unique and complex service portfolio, which on this scale, can only be found in few places in the world.
The activity of CCP focuses on three main areas:
The first being genome editing (mainly in laboratory rodents), which is currently performed primarily using the programmable nuclease (e.g. CRISPR/Cas9). CCP offers this service to researchers from around the world, thus facilitating the development of animal models to study human diseases.
Secondly, CCP focuses on phenotyping, i.e. comprehensive characterization of genetically modified models in order to describe functions of studied gene with an informative mutation. CCP is able to investigate all main physiological systems and reveal how and where the gene functions. As CCP closely cooperates with the partners from international consortia, all procedures and technologies are standardized, which improves results reproducibility.
CCP develops not only new technologies for genome editing and for characterization of physiological functions but provides also a service in pharmacokinetics and toxicology, therefore contributing to the development of new medicaments in the academic or commercial sphere. This preclinical research represents the third area of the CCP activities.
Altogether, CCP’s scope is very broad, ranging from genetics and molecular biology through physiological disciplines, biochemistry to technology disciplines including mass spectrometry. CCP is a member of INFRAFRONTIER (European Research Infrastructure for Phenotyping, Archiving and Distribution of Model Mammalian Genomes) and a member of worldwide consortia IMPC (International Mouse Phenotyping Consortium). CCP works together with IMPC members on a very ambitious goal, which is the description of function of all mammalian genes.
The talk will include also examples of 2 ongoing scientific projects.
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