The Regulation of Lymphocyte Development and Activation by the ZFP36 RNA Binding Proteins
7 March 2019
Dr. Martin Turner
Babraham Institute, United Kingdom
We aim to characterize fundamental mechanisms controlling lymphocyte development and function throughout the life-course. These include understanding the roles of RNA binding proteins in lymphocyte development and activation.
In the future explaining how these are integrated with signal transduction pathways, microRNA and transcription factor networks will be an important step towards a systems level understanding of immunity.
Find more information here.
About the lecture
The rapid changes in gene expression that promote developmental transitions, stress responses and proliferation are controlled by signal-mediated co-ordination of transcriptional and post-transcriptional processes.
Understanding the mechanics of these processes and the contexts in which they are employed during hematopoiesis and the immune challenge is a goal towards which important progress has been made in recent years.
In my presentation, I will provide evidence that RNA binding proteins (RBP) belonging to the ZFP36 family regulate lymphocyte development and act within populations of mature lymphocytes to promote homeostasis and limit T cell activation. At the molecular level, the ZFP36 proteins limit the expression of transcripts that promote proliferation. The integration of the function of these RBP with signaling pathways and the relevance to autoimmunity will be discussed.