Lecture will be held in English

Hosted by

Marek Mráz

About the lecture

Contribution of lncRNAs to the Generation of Drug-tolerant Persister Cells

Long non-coding RNAs (lncRNAs) generated from remote areas of the human genome constitute a major source of innovation for the adaptation to the numerous stresses encountered by cancer cells during progression and therapy resistance. As such, research in this field offers a unique opportunity to study melanoma evolution and unveil potentially novel biology.  Over the years, we have characterised several novel transcripts interacting with the translational machinery, either in the mitochondria or in the cytosol, and affecting the generation of drug-tolerant cells. These transcripts represent previously unexplored cancer-specific vulnerabilities and thus extend the palette of therapeutic opportunities to include RNA-based medicines.

Registration for lunch with the speaker /for Ph.D. students/

The sponsored lunch usually takes place in the Campus River restaurant. Please meet the speaker and other students at 12:45 at the reception desk at the main entrance (building B22, see the map below).